Despite being awarded multiple Nobel prizes, Organic chemistry still struggles to bridge fundamental knowledge gaps, such as deleting, inserting, and replacing specific atoms or functional groups and forging bonds at and between sp³-hybridized carbon centers through cross-coupling reactions. Accordingly, our research aims to overcome prevailing challenges in Organic chemistry by developing 1) unprecedented molecular editing transformations and 2) electrochemical radical cross-coupling reactions. In designing innovative synthetic methodologies, we will tap into the potential of transition-metal catalysis, radical chemistry and synthetic electrochemistry. By design, these reactions will be highly practical, reproducible and scalable, enabling us to operate under complex settings, including in late-stage functionalization of drug-like molecules. Using this approach, we will provide access to new complex chemical compounds with superior properties (e.g., bioactivity) in a significantly reduced step count, thereby avoiding lengthy de novo syntheses and accelerating drug discovery.